All but one local electoral area in the region has a 14 day incidence rate higher than the national rate of 373.
In Manorhamilton Co. Leitrim, as of Monday, it was 397.4, while South Donegal had a rate of 694.5.
In the Sligo/Drumcliffe Local Electoral Area, the figure is 362.1, Sligo/Strandhill is on 407 while Ballymote/Tubbercurry has a rate 374.1 per 100,000 population.
Carndonagh in Co. Donegal has the highest rate nationally at 2,110.
Donegal GP, Dr Ciaran Ó Fearraigh says the virus is not confined to the unvaccinated.