Ballyjamesduff in county Cavan has the highest 14-day incidence rate than any other local area in the country at over 651.
Lifford Stranorlar in county Donegal has risen in the past week to a rate of 610.
There are concerns about the situation in cities with Cork South-Central and Galway City Central both having rates of more than 550.
While, Gorey in county Wexford has seen a rise of over 400 percent in the past week to have a rate of 533.
Household visits are banned nationwide as new restrictions came into effect overnight.
While Donegal, Cavan and Monaghan are now under level 4 restrictions, meaning shops that sell non-essential items are not allowed to open for four weeks.
In addition, no more than six people from two households can meet outdoors.
Chief Medical Officer Dr. Tony Holohan says they are working on additional guidance for people who live alone.