Garda Forensic Collision Investigators are currently at the scene of crash on the main Dowra to Drumkeerin Road.
The single vehicle crash happened at around 8pm last night around 10 minutes outside Drumkerrin.
Manorhamilton Gardai says one man was taken to hospital following the crash however they cannot confirm the extent of his injuries.
The road is expected to re-open at approximately 8 or 9pm tonight.
Motorists are advised that local diversions are in place.