The N4 on the Boyle side of Carrick on Shannon is closed following an accident involving a lorry.
Diversions are in place but motorists are warned back roads may not yet have been gritted.
There are reports of ice on secondary routes throughout the region.
A single vehicle accident has occurred on the N16 at Cherrybrook, about two kilometres the Glenfarne side of Manorhamilton.
Traffic is down to one lane in that area.
Meanwhile, there are reports of slippery conditions following snowfall on the N15 around Barnsmore Gap in Donegal.
The Collooney to Coolaney road in Sligo is also reported to be slippery, as well as the roundabouts on the N4 at Collooney.
Road conditions are also slippery in the South Sligo and Boyle areas.